There is certainly no shortage of improbable crossovers in superhero comics. But this bit of cross-promotion between Marvel and NPR's program This American Life may rank near the top of the list:
This is a limited-edition print that TAL is currently selling on their website. The art is taken from a recent X-Men comic featuring art from Michael Allred. At some point the story features Wolverine and Nightcrawler on a road trip, during which they tune in to a broadcast of This American Life. That word balloon features host Ira Glass doing his familar intro:
The theme this week? Corporate Synergy!